Most recently, she directed a feature documentary about maternal health in the United States for Paramount/CBS. She is executive producer of "Turning Point: The Bomb and the Cold War," a nine-part Netflix series (Mar. 2024) and producer of "Turning Point: 9/11 and the War on Terror," a five-part Netflix series (Sept. 2021), both directed by Brian Knappenberger. She also co-produced the twice Emmy-nominated, two-part HBO film "Agents of Chaos" (Sept. 2020) about Russian interference in the 2016 election, directed by Oscar-winning director Alex Gibney.

She spent eight years contributing original investigative reporting to the CBS Evening News and CBS This Morning. She won Emmys in 2018 (Air Force Academy sexual assault) and 2017 (Wounded Warrior Project charity) for the Investigative Reporting category; a second place National Headliners Award and an honorable mention from the White House Correspondents Association (Air Force Academy); and she was a finalist for the Scripps Howard investigative reporting award (Wounded Warrior Project). She has shared six other Emmy nominations for her contributions in the news and documentary field.

She spent the early part of her time on the CBS News investigative team investigating the healthcare of veterans, and the consequences of war on civilians and cultural heritage in the Middle East. She also contributed reporting in countless breaking news events. Her past stories were among those honored with a 2015 Edward R. Murrow Award for Continuing Coverage of the War Against ISIL, and the 2014 Alfred I. duPont-Columbia University Award for its coverage of the Sandy Hook massacre.

Before joining CBS News, Janisch associate-produced a five-part series for PBS “Wide Angle” called “Women, War & Peace," which won the 2011 Overseas Press Club award for best television documentary on international affairs, the 2012 Gracie Award for outstanding series, and a 2012 Television Academy Honors award. Janisch associate-produced an hour-long documentary for the series about the armed conflict in Colombia called "The War We Are Living," which won the 2011 Overseas Press Club award for Best Latin America reporting.

She began her career in the summer of 2009 as an intern at CBS News “60 Minutes," where she contributed research to an investigation by Lesley Stahl into the increasing reliance by some state governments on casino revenue.

Janisch has been an adjunct professor of video journalism and investigative reporting at Columbia Journalism School since 2017.